Treatment of dermatophyte onychomycosis with terbinafine (Lamisil) pulse therapy
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چکیده
منابع مشابه
Short term treatment of dermatophyte onychomycosis with terbinafine.
OBJECTIVE To evaluate the effect of short term treatment with terbinafine on dermatophytosis. DESIGN Multicentre, randomised, double blind placebo controlled trial of 250 mg/day terbinafine for 12 weeks in dermatophyte onychomycosis. SETTING Eight dermatology centres in the United Kingdom. PATIENTS 112 patients (mean age 44, range 19-78), 99 with mycologically proved toenail infections an...
متن کاملItraconazole pulse therapy for dermatophyte onychomycosis in children.
BACKGROUND Onychomycosis, or fungal infection of the nail, can occur in prepubertal children. However, its diagnosis is often missed or the condition is inappropriately treated with topical medication. Griseofulvin has been the therapy of choice, but even long-term treatment is associated with a poor cure rate and high rate of relapse. Trials with adult patients have shown that itraconazole pul...
متن کاملThe successful treatment of Trichophyton rubrum nail bed (distal subungual) onychomycosis with intermittent pulse-dosed terbinafine.
BACKGROUND The standard treatment of Trichophyton rubrum nail bed onychomycosis (or distal subungual onychomycosis [DSO]) with daily terbinafine for 12 weeks involves treating for a fixed period shorter than the time required for complete replacement of the nail bed and overlying nail plate by normal growth. The same total amount of terbinafine pulse-dosed for approximately 12 months would trea...
متن کاملTreatment of Dermatophytic Onychomycosis with Intermittent and Continuous Terbinafine Regimens
The treatment of onychomycosis is a difficult and long-standing course because of the relatively low success and high recurrence rates and the necessity of laboratory monitoring for the traditional oral antifungal agents. The introduction of newer systemic antifungal drugs such as triazoles (itraconazole and fluconazole) and allylamines (terbinafine) offer an increased cure rate, a broader spec...
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onychomycosis. Clin Exp Dermatol 1987;12:175-7. 8 Petranyi G, Ryder NS,-Stutz A. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 1984;224: 1239-41. 9 Stutz A. Synthesis and structure-activity correlations within allylamine antimycotics. Ann N Y Acad Sci 1988;544:46-62. 10 Van de Bossche H, Willemsens G, Cools W, Lauwers WFJ, Lejeune...
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ژورنال
عنوان ژورنال: Journal of IMAB - Annual Proceeding (Scientific Papers)
سال: 2012
ISSN: 1312-773X
DOI: 10.5272/jimab.2004101.45